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| Details: | |
| Tested Applications | WB, ELISA |
| Target Information | Sigma 70 is a 70kDa transcription factor of E. coli RNA polymerase |
| Product Format | Ascites |
| Alternate Names | RNA pol sigma 70, rpoD, sigma D |
| Clone | 2G10 |
| Host | Mouse |
| Isotype | IgG2b |
| Immunogen | Recombinant Protein |
| Epitope | a.a. 470 - 486 |
| Relevance | RNA polymerase transcribes DNA to synthesize RNA. Prokaryotes contain a single RNA polymerase- core RNA polymerase. RNA polymerase sigma 70 (also known as RNA pol sigma 70 and rpoD) is one of a family of sigma factor subunits required for specific promoter recognition and initiation. RNA pol sigma 70 is the major ?housekeeping? sigma factor responsible for RNA polymerase recognition of the majority of promoters necessary to transcribe bacterial genes expressed in expansion. |
| Specificity | E. coli Sigma 70 (strain MG1655) |
| Reported Reactivity | Chlamydia trachomatis, Mycobacterium smegmatis, Staphylococcus aureus, Bordetella pertussis, Rhodobacter sphaeroides, Vibrio parahaemolyticus, Pseudamonas aeruginosa, Agrobacterium tumefaciens, Streptocoddus faecalis, Arthrobacter globiformis.Reported not to react with Borellia burgdorferi. |
| Reported Applications | Transcription inhibition, IP |
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