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Santa Cruz/Paxilline (CAS 57186-25-1)/sc-3588

Paxilline(CAS57186-25-1)

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应用；Paxilline is a selective and reversible calcium-activated potassium channel blocker

CAS号码:57186-25-1

纯度:≥97%

分子量:435.55

分子式:C₂₇H₃₃NO₄

Supplemental Information:This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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Paxilline is an indole alkaloid isolated from Penicillium paxilli. Paxilline has been shown to selectively and reversibly block the high conductance Ca²⁺-activated K⁺ channel. In neutrophils, Paxilline blockage of Maxi-K channels decreased the alkalinization of phagocytic vacuoles and inhibited the microbicidal process. When paxilline was applied to the smooth muscle of the rat vas deferens at more positive potentials than -40 mV up to 15 mV, significant depolarization of the smooth muscle contractions was observed. Paxilline is an inhibitor of MaxiKα, IP3R and SERCA.

参考文献

1. Cole, R.J., et al. 1974. Can. J. Microbiol. 20: 1159-1162. PMID: 4425383 2. Vázquez, J., et al. 1990. J. Biol. Chem. 265: 15564-15571. PMID: 1697593 3. Knaus, H.G., et al. 1994. Biochemistry. 33: 5819-5828. PMID: 7514038 4. Strøbaek, D., et al. 1996. Neuropharmacology. 35: 903-914. PMID: 8938721 5. Sanchez, M. and McManus, O.B. 1996. Neuropharmacology. 35: 963-968. PMID: 8938726 6. Young, C., et al. 1998. Curr. Genet. 33: 368-377. PMID: 9618588 7. Longland, C.L., et al. 2000. Eur. J. Pharmacol. 408: 219-225. PMID: 11090637 8. Femling, J.K., et al. 2006. J. Gen. Physiol. 127: 659-672. PMID: 16702353 9. Kryshtal", D.O., et al. 2007. Fiziol Zh. 53: 67-74. PMID: 18080495

物理状态:

Solid

来源于:

Penicillium paxilli

溶解度:

Soluble in DMSO (50 mg/ml), acetone (5 mg/ml), and chloroform (10 mg/ml).

保存:

Store at -20° C

熔点:

252° C

沸点:

648.8° C at 760 mmHg (Predicted)

密度:

1.31 g/cm³ (Predicted)

折射率:

n²⁰_D 1.66 (Predicted)

仅供科研使用。不可用于诊断或治疗。

德国水公害等级:

RTECS:

DJ2830000

PubChem CID:

4697

MDL 号码:

MFCD00083464

SMILES:

CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O

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引用1 - 10 的 14

PMID: # 26426046Maragos, CM. et al. 2015. Toxins (Basel). 7: 3903-15.

PMID: # 23345219Cuddapah, VA. et al. 2013. J. Neurosci. 33: 1427-1440.

PMID: # 22049206Cuddapah, VA. et al. 2012. Am. J. Physiol., Cell Physiol. 302: C527-38.

PMID: # 22992678McFerrin, MB. et al. 2012. Am. J. Physiol., Cell Physiol. 303: C1070-8.

PMID: # 20139089Cuddapah, VA. et al. 2010. J. Biol. Chem. 285: 11188-96.

PMID: # 19052171Kim, EY. et al. 2009. Mol. Pharmacol. 75: 466-477.

PMID: # 19778436Wondergem, R. et al. 2009. J. Biomed. Sci. 16: -.

PMID: # 18480178Kim, EY. et al. 2008. Am. J. Physiol. Renal Physiol. 295: F235-F246.

PMID: # 17519950Yeung, SY. et al. 2007. Br. J. Pharmacol. 151: 758-770.

PMID: # 16857962Seubert, JM. et al. 2006. Circ. Res. 99: 442-450.