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TTP LabTech/dragonfly discovery syringes/4150-07200

Cytoplasmicadapterregulatingreceptorsofthesignalinglymphocyticactivationmolecule(SLAM)familysuchasCD84,SLAMF1,LY9andCD244.InSLAMsignalingseemstocooperatewithSH2D1A/SAP.Playsaroleinregulationofeffectorfunctionsofnaturalkiller(NK)cellsbycontrollingsignaltransductionthroughCD244/2B4withouteffectingitstyrosinephosphorylation;downstreamsignalinginvolvesPLCG1andERKactivation.ActivationofSLAMF7-mediatedNKcellfunctiondoesnoteffectreceptortyrosinephosphorylationbutdistalsignaling(Bysimilarity).InthecontextofNKcell-mediatedcytotoxicitydoesnotenhanceconjugateformationwithtargetcellsbutstimulatespolarizationofthemicrotubule-organizingcenterandcytotoxicgranulestowardtheNKcellsynapse.NegativelyregulatesCD40-inducedcytokineprocuctiondendriticcellsdownstreamofSLAMfamilyreceptorsprobablybyinducingactivationofthePI3Kpathwaytoinhibitp38MAPKandJNKactivation(Bysimilarity).||Applications:|SuitableforuseinELISA,WesternBlot,Immunohistochemistry.Otherapplicationsnottested.||RecommendedDilution:|Optimaldilutionstobedeterminedbytheresearcher.||StorageandStABIlity:|Maybestoredat4°Cforshort-termonly.Aliquottoavoidrepeatedfreezingandthawing.Storeat-20°C.Aliquotsarestablefor12monthsafterreceipt.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.ProductType:Pab|Isotype:IgG|Host:rabbit|Concentration:~1mg/ml|Form:SuppliedasaliquidinPBS,pH7.3,0.02%sodiumazide,50%glycerol.|Purity:Purifiedbyimmunoaffinitychromatography.|Immunogen:SH2domaincontaining1B|Specificity:RecognizesSH2D1B.SpeciesCrossreactivity:human,mouse,rat||ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplicationswithouttheexpressedwrittenauthorizationofUnitedStatesBIOLOGical.
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