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BioX cell/InVivoMAb anti-mouse PD-L2 (B7-DC)/BE0112/100MG

TheTY25monoclonalantibodyreactswithmousePD-L2(programmeddeathligand2)alsoknownasB7-DCorCD273.PD-L2isa25kDatypeItransmembraneproteinthatbelongstotheB7familyoftheIgsuperfamily.PD-L2isexpressedonmonocytes,macrophagesandsubsetsofdendriticcells.PD-L2bindstoitsreceptor,PD-1,foundonCD4andCD8thymocytesaswellasactivatedTandBlymphocytesandmyeloidcells.EngagementofPD-L2withPD-1leadstoinhibitionofTCR-mediatedTcellproliferationandcytokineproduction.TheTY25antibodyhasbeenreportedtoblockPD-1mediatedinteractionsinvivo.

Isotype

RatIgG2a, κ

RecomendedIsotypeControl(s)InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol
RecommendedInVivoPureDilutionBufferInVivoPurepH7.0DilutionBuffer
Immunogen

MousePD-L2transfectedcellline

ReportedApplications
  • invivoPD-L2blockade
  • invitroPD-L2blockade
  • Immunohistochemistry(frozen)
  • Flowcytometry
Endotoxin
  • <2EU/mg(<0.002EU/μg)
  • DeterminedbyLALgelclottingassy
Purity
  • >95%
  • DeterminedbySDS-PAGE
Formulation
  • PBS,pH7.0
  • ContainsnostABIlizersorpreservatives
Sterility

0.2μMfiltered

Production

Purifiedfromtissueculturesupernatantinananimalfreefacility

Purification

ProteinG

Storage

Undilutedat4°Cinthedark

References
SDSSheet
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