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BioX cell/InVivoPlus anti-mouse CD40L (CD154)/BP0017-1/5MG188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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BioX cell/InVivoPlus anti-mouse CD40L (CD154)/BP0017-1/5MG

TheMR-1monoclonalantibodyreactswithmouseCD154alsoknownasCD40ligand.CD154existsasa39kDaaccessorymoleculeandbelongstotheTNFsuperfamilyofcytokines.CD154isprimarilyexpressedonthesurfaceofactivatedCD4+Tlymphocytesbutcanalsobeexpressedbyplatelets,mastcells,macrophages,basophils,NKcells,Blymphocytes,CD8+Tlymphocytesaswellasnon-hematopoieticcellsincludingsmoothmusclecells,endothelialcells,andepithelialcells.CD154signalsthroughCD40andisthoughttoplayakeyroleinTandBlymphocytecostimulation.TheMR-1monoclonalantibodyhasbeenreportedtoinhibitinvitroactivationofBlymphocytesbyblockingthebindingofCD154withCD40onThelpercellsaswellasinhibittheformationofgerminalcentersanddisruptantigen-specificTcellresponses.Additionally,theMR-1antibodyblocksinteractionsofTcellsandantigen-presentingcellsinvitroandblocksthedevelopmentofexperimentalautoimmunediseaseinvivo.

Isotype

ArmenianHamsterIgG

RecomendedIsotypeControl(s)InVivoPluspolyclonalArmenianhamsterIgG
RecommendedInVivoPureDilutionBufferInVivoPurepH7.0DilutionBuffer
Immunogen

ActivatedmouseTh1cloneD1.6

ReportedApplications
  • invivoblockingofCD40/CD40Lsignaling
  • invitroblockingofCD40/CD40Lsignaling
  • Westernblot
Endotoxin
  • <1EU/mg(<0.001EU/μg)
  • DeterminedbyLALgelclottingassay
Purity
  • >95%
  • DeterminedbySDS-PAGE
Aggregation
  • <5%
  • DeterminedbyDLS
Formulation
  • PBS,pH7.0
  • ContainsnostABIlizersorpreservatives
Sterility

0.2μMfiltered

Production

Purifiedfromtissueculturesupernatantinananimalfreefacility

Purification

ProteinA

Storage

Undilutedat4°Cinthedark

MurinePathogenTestResults
  • MouseNorovirus:Negative
  • MouseParvovirus:Negative
  • MouseMinuteVirus:Negative
  • MouseHepatitisVirus:Negative
  • ReovirusScreen:Negative
  • LymphocyticChoriomeningitisvirus:Negative
  • LactateDehydrogenase-ElevatingVirus:Negative
  • MouseRotavirus:Negative
  • Theiler"sMurineEncephalomyelitis:Negative
  • Ectromelia/MousepoxVirus:Negative
  • Hantavirus:Negative
  • PolyomaVirus:Negative
  • MouseAdenovirus:Negative
  • SendaiVirus:Negative
  • MycoplasmaPulmonis:Negative
  • PneumoniaVirusofMice:Negative
  • MouseCytomegalovirus:Negative
  • KVirus:Negative
References
SDSSheet
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