JENKEM/Methoxy PEG Succinimidyl Propionate/A3013-1/M-SPA-5000, 1g

Description

JenKemTechnology’s MethoxyPEGSuccinimidylPropionate (MethoxyPEGSuccinimidylPropanoate,MethoxyPEGSPA,mPEG-SPA,orM-PEGSPA)isahighqualityaminereactiveNHSPEGproductwitha stablenon-degradablelinkerbetweenthePEGpolymericchainandtheNHSester.MethoxyPEGSuccinimidylPropionate reactswiththeaminegroupoflysine(s),suchasaminesontheactiveingredientsofSomavert®,PEG-HGHantagoNIST,Pegvisomant,PeggrowthhormoneB2036[4],pegylatedgranulocytecolonystimulatingfactorMAXY-G34(PEG-CSFMAXY-G34)[5],orPuricasePEG-uricase,Pegloticase,orKrystexxya®,andrelatedbiosimilars.MethoxyPEGSuccinimidylPropionate hasa longerhydrolysishalf-lifecomparedwithM-PEG-SCM.

JenKemTechnologyoffersMethoxyPEGSPA withMW5000Da(M-SPA-5000),MW10000Da(M-SPA-10K),MW20000Da(M-SPA-20K),MW30000Da(M-SPA-30K),MW40000Da(M-SPA-40K)in1gand10gpackingsizes. DifferentMWofMethoxyPEGSPA productsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs.OtherlinearJenKemNHSesterPEGsareavailable–ifinterestedpleaseselectstablelinkerNHSPEGs,carbonatelinkerstableNHSPEGs,or cleavablelinkerNHSPEGs.JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.

BulkPEGsandGMPgradePEGsaremade-to-order.Please contactus forbulkpricing.

References:

1.Pfister,D.,etal.,Model-baseddevelopmentofanon-columnPEGylationprocess, React.Chem.Eng.,2016.

2. Ingold,O.,etal.,AreactivecontinuouschromatographicprocessforproteinPEGylation, React.Chem.Eng.,2016.

3. Pfister,D.,etal.,IntegratedprocessforhighconversionandhighyieldproteinPEGylation,Biotechnol.Bioeng., 2016.

4. GoffinV,etal., PegvisomantPfizer/Sensus.CurrOpinInvestigDrugs,2004,5:463–468.

5. https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C71718.

Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationfromethyleneoxide,enablingfaciletraceABIlityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.