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JENKEM/Methoxy PEG Acetic Acid/A3089-1/M-CM-20K

Description

MethoxyPEGAceticAcid withsuperiorqualityspecificationof ≥95%Substitution.

MethoxyPEG AceticAcid fromJenKemTechnologyisan AminePEGylationreagentreactivetowards theaminogroupoflysine(s)atpH7-8. MethoxyPEG AceticAcid ismorestablethanM-PEG-SCM. JenKemTechnologyoffersMethoxyPEG AceticAcid withMW5000(M-CM-5000),MW10000(M-CM-10K)andMW20000 (M-CM-20K),in1gand10gpackingsizes.

DifferentMWofMethoxyPEG AceticAcid productsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs. JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.

BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactus forbulkpricing.

ClickheretodownloadtheMSDS

Note:StartingJuly2016,Methoxy PEGAceticAcidisthenewnameoftheproductMethoxy PEGCarboxyl(MW5000(M-COOH-5000),MW10000(M-COOH-10K)andMW20000 (M-COOH-20K)).JenKemTechnologyhasrevisedthenameoftheproducttobetterreflectthechemical structure,asmanyotherPEGderivativeswithaCOOHgroup areofferedinourcatalog.

References:

1. Javanmardi,S.,etal.,Redox-Sensitive,PEG-ShieldedCarboxymethylPEINanogelsSilencingMicroRNA-21,SensitizesResistantOvarianCancerCellstoCisplatin,AsianJournalofPharmaceuticalSciences,2018.

2.Lassenberger,A.,etal.,IndividuallystABIlized,superparamagneticnanoparticleswithcontrolledshellandsizeleADIngtoexceptionalstealthpropertiesandhighrelaxivities.ACSAppliedMaterials&Interfaces,2017.

3.Dai,L.,etal.,Self-assembledPEG–carboxymethylcellulosenanoparticles/α-cyclodextrinhydrogelsforinjectableandThermosensitivedrugdelivery.RSCAdvances,2017,7(5):2905-12.

4.Zhao,L.,etal.,Anintraoculardrugdeliverysystemusingtargetednanocarriersattenuatesretinalganglioncelldegeneration.JournalofControlledRelease,2017.

5. Jones,S.K.,etal.,Revisitingthevalueofcompetitionassaysinfolatereceptor-mediateddrugdelivery,Biomaterials,2017.

6. Gal,N.,etal.,Interactionofsize-tailoredPEGylatedironoxidenanoparticleswithlipidmembranesandcells.ACSBiomaterialsScience&Engineering.2017,3(3):249-59.

7.Wang,Y.,etal.,Self-assemblednanoparticlesbasedonpoly(ethyleneglycol)–oleanolicacidconjugatesforco-deliveryofanticancerdrugs,RSCAdvances,2017,7(47):29591-8.

8.Chen,G.,etal.,UnimolecularMicelle-BasedHybridSystemforPerivascularDrugDeliveryProducesLong-TermEfficacyforNeointimaAttenuationinRats,Biomacromolecules,2017.

9.Farvadi,F.,etal.,Polyioniccomplexofsingle-walledcarbonnanotubesandPEG-grafted-hyperbranchedpolyethyleneimine(PEG-PEI-SWNT)foranimproveddoxorubicinloadinganddelivery:developmentandinvitrocharacterization.Artificialcells,nanomedicine,andbiotechnology,2016,1-9.

10.Li,Y.,etal.,Agraphenequantumdot(GQD)nanosystemwithredox-triggeredcleavablePEGshellfacilitatingselectiveactivationofthephotosensitiserforphotodynamictherapy, RSCAdv.,2016,6,6516-6522.

11. Jones,S.K,etal.,FolateReceptorTargetedDeliveryofsiRNAandPaclitaxeltoOvarianCancerCellsviaFolateConjugatedTrIBLockCopolymertoOvercomeTLR4DrivenChemotherapyResistance, Biomacromolecules,2016,17(1),76-87.

12. Chaudhary,R.,etal., Engineeredatherosclerosis-specificzincferritenanocomplex-basedMRIcontrastagents.JournalofNanobiotechnology,2016,14(1):1-7.

13. Abolmaali,S.S.,etal.,ChemicallycrosslinkednanogelsofPEGylatedpolyethyleneimine(l-histidinesubstituted)synthesizedviametalioncoordinatedself-assemblyfordeliveryofmethotrexate:Cytocompatibility,cellulardeliveryandantitumoractivityinresistantcells.MaterialsScienceandEngineering,2016,C,62,pp.897-907.

14. Brinkman,A.M.,etal.,Aminoflavone-loadedEGFR-targetedunimolecularmicellenanoparticlesexhibitanti-cancereffectsintriplenegativebreastcancer.Biomaterials,2016,101:20-31.

15. Li,C.etal., Aself-assemblednanoparticleplatformbasedonpoly(ethyleneglycol)–diosgeninconjugatesforco-deliveryofanticancerdrugs, RSCAdv.,2015,5,74828-74834.

16. Najafi,H.,etal.,SerumresistantandenhancedtransfectionofplasmidDNAbyPEG-stabilizedpolyplexnanoparticlesofL-histidinesubstitutedpolyethyleneimine,MacromolecularResearch, 2015,23:7,p.618-627.

17. Saraswathy,M.,etal.,MultifunctionaldrugnanocarriersformedbycRGD-conjugatedβCD-PAMAM-PEGfortargetedcancertherapy,ColloidsandSurfacesB:Biointerfaces,2015,126,p.590-597.

18. Chen,G.,etal.,Multi-functionalself-fluorescentunimolecularmicellesfortumor-targeteddrugdeliveryandbioimaging,Biomaterials 2015,47,P.41-50.

19. Xiong,D,etal.,GX1-mediatedanionicliposomescarryingadenoviralvectorsforenhancedinhibitionofgastriccancervascularendothelialcells,InternationalJournalofPharmaceutics,2015,496:2,p.699-708.

20.Guo,J., TheranosticUnimolecularMicellesBasedonBrush-ShapedAmphiphilicBlockCopolymersforTumor-TargetedDrugDeliveryandPositronEmissionTomographyImaging,ACSAppl.Mater.Interfaces,2014,6(24),p:21769–21779.

21.Xu,P.,etal.,Hydrogen-bondedandreduction-responsivemicellesloadingatorvastatinfortherapyofbreastcancermetastasis.Biomaterials,2014,35(26),p.7574-7587.

22.Gajbhiye,V.,etal.,Drug-loadednanoparticlesinducegeneexpressioninhumanpluripotentstemcellderivatives.Nanoscale,2014,6(1),p.521-31.

23. Abolmaali,S.S.,etal., Sequentialoptimizationofmethotrexateencapsulationinmicellarnano-networksofpolyethyleneimineionomercontainingredox-sensitivecross-links,InternationalJournalofNanomedicine,2014,9:2833-2848.

24. Guo,J.,etal., Image-guidedandtumor-targeteddrugdeliverywithradiolabeledunimolecularmicelles, Biomaterials,2013,34(33),p: 8323–8332.

25.Gao,X.,etal.,Prostatestemcellantigen-targetednanoparticleswithdualfunctionalproperties:invivoimagingandcancerchemotherapy.IntJNanomedicine,2012,7:p.4037-51.

26.Jiang,X.,etal., Self-aggregatedpegylatedpoly(trimethylenecarbonate)nanoparticlesdecoratedwithc(RGDyK)peptidefortargetedpaclitaxeldeliverytointegrin-richtumors, Biomaterials,2011,32(35),p:9457–9469.

Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationdirectlyfromethyleneoxide,enablingfaciletraceabilityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.

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