JENKEM/Methoxy PEG Succinimidyl Hexanoate/A3148-1/M-SHA-20K,1g

Description

MethoxyPEGSuccinimidylHexanoatewithsuperiorqualityspecificationof ≥95%Substitution.

JenKemTechnology’sMethoxyPEGSuccinimidylHexanoate (MethoxyPEGSHA)isahighqualityaminereactivePEGproductwithastablenon-degradablelinkerbetweenthePEGpolymericchainandtheNHSester.MethoxyPEGSuccinimidylHexanoate reactswiththeaminegroupoflysine(s)atpH7-8.MethoxyPEGSuccinimidylHexanoatehasa longerhydrolysishalf-lifecomparedwithM-PEG-SCMandM-PEG-SBA.JenKemTechnologyoffersMethoxyPEGSHA withMW5000Da(M-SHA-5000),andMW20000Da(M-SHA-20K),in1gand10gpackingsizes.

DifferentMWofMethoxyPEGSHA productsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs.OtherlinearJenKemNHSesterPEGsareavailable–ifinterestedpleaseselectstablelinkerNHSPEGs,carbonatelinkerstableNHSPEGs,or cleavablelinkerNHSPEGs.JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.

BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactus forbulkpricing.

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References:

1.Mesken,J.,etal.,Modifyingplasmid-loadedHSA-nanoparticleswithcellpenetratingpeptides–Cellularuptakeandenhancedgenedelivery,Internationaljournalofpharmaceutics,2017,522(1):198-209.

2.Look,L.,etal.,Ligand-ModifiedHumanSerumAlbuminNanoparticlesforEnhancedGeneDelivery,MolecularPharmaceutics, 2015,12(9),3202-3213.

3.FahrlanderE.,etal.,PEGylatedhumanserumalbumin(HSA)nanoparticles:preparation,characterizationandquantificationofthePEGylationextent, Nanotechnology,2015,26(14):145103.

4. Gossmann,R.,etal.,ComparativeexaminationofadsorptionofserumproteinsonHSA-andPLGA-basednanoparticlesusingSDS–PAGEandLC–MS,EuropeanJournalofPharmaceuticsandBiopharmaceutics,2015,93,p.80-87.

Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationdirectlyfromethyleneoxide,enablingfaciletraceABIlityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.