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ECM BIOSCIENCES/Adiponectin (C-terminal region) M576 Antibody/100 μl/AM5761

Adiponectin is an adipokine that is secreted primarily from adipocytes and functions in glucose regulation and lipid metabolism. It has also been shown to play a major role in energy homeostasis. Studies report adiponectin secretion in bone, mammary glands, salivary glands, and cardiac tissue in limited quantities. It forms a homo-oligomeric structure and is homologous to complement factor C1q, collagen type VIII, and collagen type X. In humans and mice with low adiponectin levels, increased obesity and insulin resistance is observed. Adiponectin, typically an anti-inflammatory agent, has been shown to exert pro-inflammatory effects in nonmetabolic disease such as irritable bowel syndrome. Low levels of adiponectin in blood have been correlated with higher incidence and poorer prognosis in several cancers, including breast cancer.

References

Nalabolu, M. et al. (2014). Int J Hem Onc St Cell Res8(1):31 Waki, H. et al. (2003) J Biol Chem. 278(41):40352Hu, E. et al. (1996). J Biol Chem. 271(18):10697Scherer, P.E. et al. (1995). J Biol Chem. 270(45):26746

Western blot analysis of mouse white adipose tissue (lanes 1 & 3) and human recombinant full length adiponectin (lanes 2 & 4). The blot was probed with mouse monoclonals anti-Adiponectin (C-terminal) antibody M577(lanes 1 & 2) or anti-Adiponectin (C-terminal) antibody M576(lanes 3 & 4).

Clone (M576) was generated from a recombinant protein that included amino acid residues within the C-terminal region of mouse Adiponectin. This sequence has high homology with similar regions in rat and human adiponectin.

*For more information, see UniProt Accession Q60994

Mouse monoclonal antibody purified with protein G chromatography is supplied in 100µl phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide. Store at –20°C. Stable for 1 year.

The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.

The antibody was purified using Protein G chromatography. This antibody detects a 30 kDa* protein on SDS-PAGE immunoblots of human and mouse serum, as well as detects full length human and mouse recombinant proteins.

*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blotmobilities of known proteins with similar MW.

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ECM BIOSCIENCES/Adiponectin (C-terminal region) M576 Antibody/100 μl/AM5761

References

*For more information, see UniProt Accession Q60994

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