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Recombinant Human cIAP-2/HIAP-1 is a RING finger Ubiquitin ligase (E3) that functions downstream of a Ubiquitinactivating (E1) enzyme and a Ubiquitin-conjugating (E2) enzyme to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial cIAP-2 concentration of 0.2-1 μM.
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins.Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration.The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard.In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
| Formulation | X mg/ml (XμM) in 50 mM HEPES pH 8.0, 500 mM NaCl, 10% (v/v) Glycerol, 5 mM TCEP |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Cellular inhibitor of apoptosis protein 2 (cIAP-2, also known as BIRC3, API2, and HIAP-1) is a member of theinhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. Structurally, cIAP-2 is comprised of 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). The ring finger domain of cIAP-2 functions as an E3 ubiquitin ligase to ubiquitinate specific targets such as RIPK1-4, CASP3, 7, and 8, TRAF1, and BCL10. cIAP-2 is an important regulator of innate immune signaling via regulation of Toll-like receptors, Nod-like receptors and RIG-I receptors, collectively known as pattern recognitions receptors (PRRs).
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