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SPIbio/CBX1 (human recombinant)/100 µg/14768

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About Cayman

Territorial Availability: Available through Bertin Pharma only in Europe

Correlated keywords:

epigenetics heterochomatin chromodomain histones H3K9 chromoshadow domains proteins HP1 HP-1 N-terminal CSD CBXs di-methylated tri-methylated lysine 9 H3 H3K9me2 H3K9me3 BRCA2 EMSY breasts ovarian cancers DNA chromatin DDR DNA damages responses

Product Overview:The heterochromatin protein 1 (HP1) family, which consists of three isoforms HP1α (CBX5), HP1β (CBX1), and HP1γ (CBX3) are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain (CSD), and a hinge domain which connects the two.{23468} Extensive post-translational modifications have been observed and mapped on the CBX proteins.{23471} The chromodomain of CBX1 has been shown to recognize di- and tri-methylated lysine 9 on histone H3 (H3K9me2 and H3K9me3), with a preference for H3K9me3. Binding of CBX1 to methylated histones leads to gene silencing and heterochromatin formation.{20846,20874} The CSD region of CBX1 is responsible for homodimerization and interaction with a number of non-histone chromatin-associated proteins, including the BRCA2-interacting protein EMSY, which may be involved in the development of breast and ovarian cancer.{23470,20843,23466} CBX1 also helps to reorganize chromatin as part of the DNA damage response systems by binding to sites of DNA damage through the CSD region.{20844,23467}

Size	100 µg
Shipping	dry ice
Stability	Store at -80 degrees; shelf life 180 days
Formulation	50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352204

Technical File

MSDS

Cayman Chemical"s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

AccreditationsISO/IEC 17025:2005ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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SPIbio/CBX1 (human recombinant)/100 µg/14768