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| Poly(I:C)Toll-like receptor 3 (TLR3) agonist |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
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Cell lines | Dendritic cell |
Preparation method | Soluble in sterile water. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
Reacting condition | 12.5 mg/ml, 3 days |
Applications | Treatment of immature DC for 72 h with poly(I:C) resulted in the typical DC morphology and induced significant maturation. Poly(I:C)-treated DC remained stable in phenotype after cytokine withdrawal. Poly(I:C)-treated DC down-regulated pinocytic activity. Poly(I:C)-treated DC produced high levels of IL-12 and low levels of IL-10. |
Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
References: [1]. Verdijk R M, Mutis T, Esendam B, et al. Polyriboinosinic polyribocytidylic acid (poly (I: C)) induces stable maturation of functionally active human dendritic cells[J]. The Journal of Immunology, 1999, 163(1): 57-61. | |
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| Cas No. | 24939-03-5 | SDF | Download SDF |
| Synonyms | N/A | ||
| Chemical Name | ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate compound with ((2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (1:1) | ||
| Canonical SMILES | O[C@@H]([C@H](N1C(NC=NC2=O)=C2N=C1)O[C@@H]3COP(O)(O)=O)[C@@H]3O.O[C@H]([C@@H](COP(O)(O)=O)O[C@H]4N5C=CC(N)=NC5=O)[C@@H]4O | ||
| Formula | C19H27N7O16P2 | M.Wt | 671.41 |
| Solubility | ≥21.5mg/mL in H2O, <0.4mg l="" in="" dmso=""> | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
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