产品资料

Quansys Biosciences/Q-Plex™ Human Chemokine (4-Plex)/96-well solid plate/#125433HU

IL-8
IP-10
MCP-1
Rantes

Interleukin 8 (IL-8), also known as CXCL8, is a chemokine that plays a role in the recruitment and regulation of white blood cells during an innate immune response. It is a strong chemoattractant for neutrophils and other granulocytes, bringing them to the site of infection and then stimulating them to engage in phagocytosis. It is commonly secreted by macrophages that have identified a foreign pathogen but may be emitted by any cell with toll-like receptors. IL-8 plays a key role in metastasis; it was first identified as a leukocyte chemoattractant that progresses melanoma by directly inducing angiogenesis and migration of melanoma cells. Serum IL-8 levels are directly correlated with the degree of metastatic melanoma and overall tumor count. High levels of IL-8 in a pregnant mother are associated with schizophrenia in her child and high levels in adults with schizophrenia reduces the effectiveness of antipsychotic medications. IL-8 dysregulation is also involved in cystic fibrosis, where it recruits an excessive number of white blood cells to the lungs, resulting in tissue damage.

Interferon gamma-induced protein 10 (IP-10), also known as C-X-C motif chemokine 10 (CXCL10) or small-inducible cytokine B10, is a small cytokine with diverse roles in the immune system. Many cell types release IP-10 in response to stimulation from IFN-γ. It has chemotactic properties for activated T cells, monocytes, macrophages, natural killer cells, and dendritic cells. It promotes the adhesion of T cells to endothelial cells and has strong anti-tumor properties. It inhibits bone marrow colony formation and angiogenesis. IP-10 expression has been associated with HIV-1 infection, where it contributes to the accumulation of activated T cells in the cerebrospinal fluid compartment of infected individuals. The retroviral transactivator, HIV-1 Tat, is a potent inducer of IP-10 expression in astrocytes. IP-10 expression has also been shown to be significantly elevated in astrocytes within the brains of Alzheimer’s disease patients, where its expression is associated with senile plaques. Higher levels of IP-10 are documented in Hepatitis C patients who respond poorly to antiviral treatment.

Monocyte chemoattractant protein 1 (MCP1), also known as chemokine (C-C motif) ligand 2 (CCL2) and small inducible cytokine (A2MCP-1), is a chemokine that plays a role in the body’s response to tissue injury and infection. It is produced by many cell types in response to tissue damage, and is a chemoattractant to monocytes, basophils, memory T cells, and dendritic cells. MCP-1 is commonly found at the site of tooth and bone injuries or infections, where it is expressed by osteoclasts and osteoblasts. It is also produced by cells of the nervous system and is implicated in many inflammatory neurological disorders. Elevated MCP-1 levels are often associated with sepsis, Crohn’s disease, lupus nephritis, amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, acute pancreatitis, and atherosclerosis.MCP-1 is also upregulated in several cancers including gastric carcinoma, esophageal squamous cell carcinoma, malignant glioma, and ovarian, pancreatic, bladder, and breast cancers.

Regulated on activation, normal T cell expressed and secreted (RANTES), also known as Chemokine (C-C motif) ligand 5 (CCL5) is a cytokine that mediates inflammatory response of the immune system. It is chemotactic to T lymphocytes, basophils, and eosinophils. RANTES activates and increases the cytotoxicity and proliferation of natural killer cells. It is secreted by fibroblasts, platelets, and T cells at the site of inflammation. RANTES is also involved in the progression and metastasis of some malignant tumors where it may promote migration of cancer cells. Its expression is upregulated in the white adipose tissue of obese individuals and may be involved in obesity related inflammation. RANTES is strongly HIV suppressive, preventing replication of certain HIV strains and is currently under investigation as a therapeutic for the virus.

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Quansys Biosciences/Q-Plex™ Human Chemokine (4-Plex)/96-well solid plate/#125433HU