Lipocalin-2 (LCN2) Rapid Human ELISA Kit
For the quantitative determination of human Lipocalin-2 (LCN2) concentrations in serum, plasma, urine and cell culture supernate samples.Lipocalin-2(LCN2), also known as neutrophil gelatinase associated lipocalin (NGAL), 24p3, or neutrophil lipocalin (NL), is a 25-kDa secretory glycoprotein (1). LCN2 has been implicated in a variety of cellular processes including the innate immune response, differentiation, tumorigenesis, and cell survival(2,3). It appears to be upregulated in various inflammation and infection conditions. Several reports suggest that LCN2 may represent a sensitive biomarker for various renal injuries(4) and is associated with several types of cancers, including breast cancer(5), ovarian, colorectal, and pancreatic cancers(6,7). Furthermore, a growing body of evidence suggests that serum levels of lipocalin-2 are correlated with obesity, insulin resistance, hyperglycemia, coronary heart disease and fatty liver disease in humans(8-11).[1] Kjeldsen, L. et al. (1993) J. Biol. Chem. 268:10425-32[2] Yang, J. et al. (2002) Mol. Cell. 10:1045-56.[3] Flo, T.H. et al. (2004) Nature 432:917-21.[4] Mishra, J. et al. (2005) Lancet 365:1231-6.[5] Yang, J. et al. (2009) Proc Natl Acad Sci U S A 106(10):3913-8.[6] Hanai, J. et al. (2005) J. Biol. Chem. 280:13641-7.[7] Lee, H.J. et al. (2005) Int. J. Cancer 118:2490-7.[8] Wang Y, et al. (2007) Clin Chem 53(1):34-41.[9] Yan QW, et al. (2007) Diabetes 56(10):2533-40.[10] Ruby LC Hoo, et al. (2008) Expert Rev. Endocrinol Metal 3(1):29-41.[11] Milner KL, et al. Hepatology [Epub ahead of print]