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axonmedchem/BAM 7/10 mg/Axon 2185

BAM 7

Based on 16 reference(s) in Google Scholar91016

Axon 2185

CAS [331244-89-4]

MF C21H19N5O2SMW 405.47

  • Purity:98%
  • Soluble in DMSO

BAM 7

Description

Selective small-molecule activator of proapoptotic BAX (IC50 value 3.3 μM) that binds to the BH3 binding domain without interacting with other BH3-binding pockets of antiapoptotic proteins or proapoptotic BAK. BAM 7 triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death.
  • References
  • Certificates
  • Categories
  • Extra info
E. Gavathiotis et al. Direct and selective small-molecule activation of proapoptotic BAX. Nat. Chem. Biol. 2012, 8, 639-645.
  • Certificate of Analysis
  • Material Safety Data Sheet
ApoptosisCell Cycle RegulationCell Signaling & Oncologyp53-Tumor SuppressionBcl
Selective small-molecule activator of proapoptotic BAX

Chemical name

4-(2-(2-ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one

Parent CAS No.

[331244-89-4]

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