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Axon 2489
CAS [105748-59-2]
MF C11H12N2S2MW 236.36
Bioavailable dithiocarbamate with affinity for indoleamine 2,3-dioxygenase (IDO; Ki value 28 μM for human IDO) showing antifungal and anticancer activity. Moreover, Brassinin suppressed both constitutive and IL-6-inducible STAT3 activation through modulation of PIAS-3 and SOCS-3, thereby attenuating tumor growth and increasing sensitivity to paclitaxel.
KEYWORDS: Brassinin | supplier | Dual IDO1/STAT3 inhibitor | CAS [105748-59-2] | L-Kynurenine | IDO1 | STAT3 | Inhibitor | IL-6 | PIAS-3 | SOCS-3 | antifungal | anticancer | natural | dithiocarbamate | paclitaxel
| T. Banerjee et al. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008 May 1;27(20):2851-7. |
| P. Gaspari et al. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2006 Jan 26;49(2):684-92. |
| J.H. Lee et al. Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel. Oncotarget. 2015 Mar 20;6(8):6386-405. |
methyl (1H-indol-3-yl)methylcarbamodithioate
[105748-59-2]
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