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Medimabs/IKK gamma (VTN2) Mouse Monoclonal Antibody/MM-0150 -- anti-IKK-y zebrafish/100 µg

  • Product Name
    IKK gamma (VTN2) Mouse Monoclonal Antibody
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Clone ID
    VTN2
  • DataSHEET
    View Datasheet (PDF)
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    Zebrafish
  • Specificity
    splice variant form
  • Format
    100 µg
  • Background
    IKK-γ, also known as NF-kappa-B essential modulator (NEMO) and inhibitor of nuclear factor kappa-B kinase subunit gamma, is the regulatory subunit of the cytoplasmic IκB kinase (IKK) complex. IKK-γ is required for activation of the IKK complex by upstream components of the NF-κB cascade. The IKK complex activates NF-κB which is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. In the cytoplasm, NFκB is maintained in an inactive form by the inhibitory protein IκB. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IκB, releasing NF- κB dimers. NF-κB dimers subsequently translocate to the nucleus and activate target genes. IKK-γ interacts preferentially with IKKβ and is required for activation of IKK complex. Recent studies suggest that IKK gamma (NEMO) may be a key molecule acting as an adapter for onco-protein specific signaling to IKKa and IKKb.
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