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| Application: | EnzymeInhibition |
| MolecularWeight: | 100-500 |
| ResearchArea: | HistoneAcetylation |
| Solubility: | DMSO,Ethanol |
| 100%Guarantee: | 6months |
AlternativeNames
5-[(2-hydroxy-5,8-dihydronaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihy.
Description
Cambinol isacell-permeableβ-naphtholcompoundthatinhibitstheNAD-dependentdeacetylaseactivityofhSIRT1andhSIRT2(IC50=56µMand59µM,respectively)inasubstrate-,butnotNAD-,competitivemanner.ItinhibitsSIRT5deacetylaseactivityonlyatmuchhigherconcentrations(IC50>300µM)andexhibitsnoinhibitionagainstclassIandIIHDACs.Cambinol-inducedapoptosisinBCL6-expressingBurkittlymphomacelllineshasbeenattributedtothehyperacetylationofBCL6andp53.ShowntoeffectivelyinhibitxenograftedDaudiBurkittlymphomagrowthinmiceinvivo.
CASNumber
14513-15-6
ChemicalFormula
C21H16N2O2S
MolecularWeight
360.4
Size
5mg
Purity
>95%
Solubility
SolubleinDMSOorEtOH
StorageTemp
-20°C