Epigentek/C646, p300/CBP Inhibitor/M310001/1 mg

AlternativeNames
(E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoicacid

Description
Cell-permeable.Areversible,p300/CBP(CREB-bindingprotein)histoneacetyltransferase(HAT)inhibitor(Ki=400nM).Specificinhibitiontop300(86%)comparedtoN-acetyltransferase,PCAF,GCN5,Rtt109,SasorMOZhistoneacetyltransferases(<10%).SuppresseshistoneH3andH4acetylationinmousefibroblastcelllines.

CASNumber
328968-36-1

ChemicalFormula
C₂₄H₁₉N₃O₆

MolecularWeight
445.4

Size
1mg

Purity
≥98%byNMR

Solubility
DMSO(25mM)

StorageTemp
-20°C