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| Application: | ELISA |
| AreasofResearch: | Immunology&Inflammation |
| Clonality: | Polyclonal |
| Conjugate: | Biotin |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | >95%,ProteinGPurified |
| Reactivity: | Human |
| 100%Guarantee: | 6months |
Background
Atypicalchemokinereceptorthatcontrolschemokinelevelsandlocalizationviahigh-affinitychemokinebindingthatisuncoupledfromclassicligand-drivensignaltransductioncascades,resultinginsteadinchemokinesequestration,degradation,ortranscytosis.Alsoknownasinterceptor(internalizingreceptor)orchemokine-scavengingreceptororchemokinedecoyreceptor.Hasapromiscuouschemokine-bindingprofile,interactingwithinflammatorychemokinesofboththeCXCandtheCCsubfamiliesbutnotwithhomeostaticchemokines.ActsasareceptorforchemokinesincludingCCL2,CCL5,CCL7,CCL11,CCL13,CCL14,CCL17,CXCL5,CXCL6,IL8/CXCL8,CXCL11,GRO,RANTES,MCP-1,TARCandalsoforthemalariaparasitesP.vivaxandP.knowlesi.Mayregulatechemokinebioavailabilityand,consequently,leukocyterecruitmentthroughtwodistinctmechanisms:whenexpressedinendothelialcells,itsustainstheabluminaltoluminaltranscytosisoftissue-derivedchemokinesandtheirsubsequentpresentationtocirculatingleukocytes;whenexpressedinerythrocytes,servesasbloodreservoirofcognatechemokinesbutalsoasachemokinesink,bufferingpotentialsurgesinplasmachemokinelevels.
Description
ACKR1PolyclonalAntibody,BiotinConjugated.Biotin.Raisedin:Rabbit.
Formulation
Liquid.0.03%Proclin300,50%Glycerol,0.01MPBS,PH7.4.
Specificity
Human
Isotype
IgG
UniprotID
Q16570
Purification
>95%,ProteinGpurified
Immunogen
RecombinanthumanAtypicalchemokinereceptor1protein(1-63AA)
Storage
Shippedat4°C.Upondeliveryaliquotandstoreat-20°C(short-term)or-80°C(long-term).Avoidrepeatedfreeze.
AlternativeNames
Atypicalchemokinereceptor1,Duffyantigen/chemokinereceptor,GlycoproteinD,Plasmodiumvivaxreceptor,ACKR1,DARC,FY,GPD
Application
ELISA
VCU0006