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Signalchem/SGK1, Active/50 ug/S06-10G-50

Overview:

SGK1isamemberoftheserum-andglucocorticoid-inducedproteinkinasethatisactivatedinvitroby3-phosphoinositide-dependentproteinkinase-1(PDK1)andinvivoinresponsetosignalsthatactivatephosphatidylinositol(PI)3-kinase(1).SGK1mRNAisexpressedinalltissuesandthelevelofSGK1mRNAisincreasedbystimulationwithserumordexamethasone.SGK1promotescellsurvivalbyphosphorylatingandinactivatingFKHRL1(2).SGKandAktdisplaydifferenceswithrespecttotheefficacywithwhichtheyphosphorylatethethreeregulatorysitesonFKHRL1.

GeneAliases:

SGK

GenbankNumber:

NM_005627

References:

1.Kobayashii,T.etal:Characterizationofthestructureandregulationoftwonovelisoformsofserum-andglucocorticoid-inducedproteinkinase.BiochemJ.1999Nov15;344Pt1:189-97.2.Brunet,A.etal:ProteinkinaseSGKmediatessurvivalsignalsbyphosphorylatingtheforkheadtranscriptionfactorFKHRL1(FOXO3a).MolCellBiol.2001Feb;21(3):952-65.

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