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Bpsbioscience/Anti-CD47 Antagonist Antibody/79065-2/100 µg

Species:Human
HostSpecies:HEK293
MW:HeavyChain:51kDa,LightChain:27kDa
Clonality:Monoclonal
Isotype:IgG1
Background:

ClusterofDifferentiation47,orCD47,playsanessentialroleincellgrowth,death,migration,andadhesion.CD47bindingtoSIRP-αmediatesphagocytosisbysendinga“donoteatme”signaltophagocytes.CD47proteinsareoftenoverexpressedbytumorcellsasameansforthemtoescapephagocytosis.Asaresult,canceroustumorcellshavetheABIlitytoproliferateandevadetheimmunesystem.

Description:
Anti-CD47recombinanthumanantagoNISTantibodyrecognizingtheSIRP-αorSIRP-үbindingregionofhumanCD47.Thisantibodyhasnotbeentestedforcross-reactivitywithanyotherspecies.
Formulation:
8mMPhosphate,pH7.4,110mMNaCl,2.2mMKCl,and20%glycerol
Purification:
ProteinAaffinitychromato-graphyfromHEK293supernatants.
Storage/Stability:
Stableforatleast12monthsat-80°C.Protectfromlight.Avoidfreeze/thawcycles.Storedilutedantibodywithcarrierprotein(BSA0.1–0.5%)at4°C,stablefor2weeks.
Application(s):
UsefulasanantagonisttoblockCD47signalingandbindingtoSIRP-αorSIRP-үinbiochemicalassays.
Reference(s):
1.Vernon-Wilson,E.F.etal.,Eur.J.Immunol.2000;30(8):2130-2137.

2.Majeti,R.etal.,Cell.2009;138(2):286-299.

ScientificCategory:
Immunotherapy
ProductType:
Antibody
Datashownislot-specific.Contactusforspecificinformationonotherlots.
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