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LifeSensors/AC1003 Chloroquine diphosphate 25mg/AC1003 Chloroquine diphosphate 25mg

Background

Chloroquinephosphateisa4-aminoquinolineanti-malarialandanti-rheumatoidagent,alsoactingasanATMactivator.Inhibitsautophagyinavarietyofcelllines1.Inducescelldeathinbreastcancercelllinesanddisplaysantitumorandantimetastaticactivityinmousemodelsofbreastcancer2.EliminatescancerstemcellsviaderegulationofJak2andDNMT13.DisplayssynergywhencombinedwiththeRafinhibitor,vemurafenib,inbraintumors4.Cellpermeableandactiveinvivo.


Application

AutophagyInhibitor


ProductInformation

Purity:           >98.0%byTLC

MW:                515.9

Formula:            C18H26ClN3.2H3O4P

CASNo.             50-63-5

PhysicalState:    Lyophilizedwhitepowder

Amount:               5mg,25mg,50mg

Solubility:           25mg/mLinwater

Storage:           Storedesiccatedassuppliedatambienttemperatureforupto2years.Storesolutionsat-20°Cforupto3months.



References

1.HBFrieboesetal.JOP201415:189
2.PDJiangetal.Biomed.Pharmacother.201064:609
3.DSChoietal.StemCells201432:2309
4.JMMulcahyLevyetal.CancerDiscov.20144:773 


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