Functionalizedvon-Hippel-Lindauproteinligand(VHL)forPROTACresearchanddevelopment;incorporatesanE3ligaseligandplusaPEGlinkerreadyforconjugationtoatargetproteinligand.PartofarangeoffunctionalizedtoolmoleculesforPROTACR&D.
Application
FunctionalizedVHLligandforPROTACs;incorporatesanE3ligaseligandplusaPEGlinker.
ProductInformation
Purity: >95%
MW: 656.23
Formula: C30H45N5O7S.HCl
CASNumber 2097971-11-2
PhysicalState: Lyophilizedwhitesolid
Quantity: 5mg;10mg;25mg
Solubility: 65mg/mLinDMSO;65mg/mLinwater
Storage: Storeat-20C.
References
1. Zengerle etal (2015)SelectivesmallmoleculeinduceddegradationoftheBETbromodomainproteinBRD4.ACSChem.Biol. 10 1770PMID: 26035625
2. Salami etal (2017)Wastedisposal-Anattractivestrategyforcancertherapy.Science 355 1163PMID: 28302825
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