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LifeSensors/PC1012 VH 032 Linker 1 (10mg)/PC1012 VH 032 Linker 1 (10mg)

Functionalizedvon-Hippel-Lindauproteinligand(VHL)forPROTACresearchanddevelopment;incorporatesanE3ligaseligandplusaPEGlinkerreadyforconjugationtoatargetproteinligand.PartofarangeoffunctionalizedtoolmoleculesforPROTACR&D.


Application


FunctionalizedVHLligandforPROTACs;incorporatesanE3ligaseligandplusaPEGlinker.


ProductInformation


Purity:         >95% 

MW:              656.23

Formula:          C30H45N5O7S.HCl

CASNumber       2097971-11-2

PhysicalState: Lyophilizedwhitesolid

Quantity:         5mg;10mg;25mg

Solubility:         65mg/mLinDMSO;65mg/mLinwater

Storage:         Storeat-20C.


References


1.    Zengerle etal (2015)SelectivesmallmoleculeinduceddegradationoftheBETbromodomainproteinBRD4.ACSChem.Biol. 10 1770PMID: 26035625

2.    Salami etal (2017)Wastedisposal-Anattractivestrategyforcancertherapy.Science 355 1163PMID: 28302825


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