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Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Application
Functionalized VHL ligand for PROTACs; incorporates an E3 ligase ligand plus a PEG linker.
Product Information
Purity: >95%
MW: 656.23
Formula: C30H45N5O7S.HCl
CAS Number 2097971-11-2
Physical State: Lyophilized white solid
Quantity: 5mg; 10mg; 25mg
Solubility: 65 mg/mL in DMSO; 65 mg/mL in water
Storage: Store at -20C.
References
1. Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem. Biol. 10 1770 PMID: 26035625
2. Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825
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