ReliaTech/Rat AntiHuman CCR3/101M279/100 µg

Clone/ABfeature:

(#7F12)

Antibodygeneration:

Thisantibodywasproducedfromahybridoma(mousemyelomafusedwithspleencellsfromamouse)immunizedwith293cellstransfectedwithhumanCCR3.

Antigen:

HumanCCR3transfected293cells

StABIlity:

Lyophilizedsamplesarestablefor2yearsfromdateofreceiptwhenstoredat-70°C.Reconstitutedantibodycanbealiquotedandstoredfrozenat< -20 °C for at least for six months without detectable loss of activity.

Reconstitution:

Reconstitutetheantibodywith500µlsterilePBSandthefinalconcentrationis200µg/ml.

Description:

CCR-3orCD193isamemberoftheseventransmembraneG-proteincoupledreceptor(GPCR)family,andisahighaffinitychemokinereceptorforthechemokineseotaxin-1(CCL11),eotaxin-2(CCL24),eotaxin-3(CCL26)andMCP-4(CCL13),buthasalsobeenreportedtobindRANTES,MCP-3andMCP-4.CD193ishighlyexpressedonthesurfaceofeosinophils,andisthekeyeosinophilchemokinereceptorresponsIBLefortheregulationofeosinophilmigrationandfunction.Inadditiontoeosinophils,CD193isalsoexpressedonCD4+TH2cells,basophils,mastcells,mononuclearphagocytes,platelets,CD34+hematopoieticProgenitorsandairwayepithelialcells.CD193likelyplaysanimportantroleinthemigrationofeosinophilsinallergicairwayinflammationandasthma.CD193canalsoserveasareceptorforHIV-1cellentry.