ReliaTech/Rat AntiMouse Resistin/103M461/100 µg

Clone/ABfeature:

(#5B54)

Antibodygeneration:

Thisantibodywasproducedfromahybridoma(mousemyelomafusedwithspleencellsfromarat)immunizedwithmouserecombinantproteinofResistin.

Antigen:

recombinantmouseResistin

Stability:

Lyophilizedsamplesarestablefor2yearsfromdateofreceiptwhenstoredat-70°C.Reconstitutedantibodycanbealiquotedandstoredfrozenat< -20 °C for at least for six months without detectable loss of activity.

Reconstitution:

Reconstitutetheantibodywith500µlsterilePBSandthefinalconcentrationis200µg/ml.

Description:

Resistinbelongstoafamilyoftissue-specificcytokinestermedFIZZ(foundininflammatoryzones)andRELM.Thethreeknownmembersofthisfamily;Resistin,RELM-αandRELM-βshareahighlyconservedC-terminaldomain,characterizedby10cysteineresidueswithauniquespacingmotifofC-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C.Resistinisanadipose-derivedcytokine(adipokine)whosephysiologicalfunctionandmoleculartargetsarelargelyunknown.StudieshaveshownthatResistinsuppressesinsulinsabilitytostimulateglucoseuptake,andpostulatedthatResistinmightbeanimportantlinkbetweenobesityandType2diabetes.OtherstudieshaveindicatedthatResistinexpressionisseverelysuppressedinobesityandthatitmayactasafeedbackregulatorofAdipogenesis.RecombinantmurineResistinisa20.2kDadisulfide-linkedhomodimericproteincomposedoftwoidentical94aminoacidchainslinkedbyasingledisulfidebond.