ReliaTech/Rabbit AntiRat VEGFD/104PA12S/100 µg

Antibodygeneration:

ProducedfromseraofrabbitsimmunizedwithanN-terminalpeptideofratdNdC-VEGF-D.Anti-ratVEGF-DIgGwaspurifiedbyaffinitychromatographywithimmobilizedProteinA.

Antigen:

N-terminalpeptide

Stability:

Thelyophilizedantibodyisstableatroomtemperatureforupto1month.Thereconstitutedantibodyisstableforatleasttwoweeksat2-8°C.Frozenaliquotsarestableforatleast6monthswhenstoredat-20°C.

Reconstitution:

Centrifugevialpriortoopening.Reconstituteinsterilewatertoaconcentrationof0.1-1.0mg/ml.

Description:

VascularendothelialgrowthfactorD(VEGF-D),alsoknownasC-fosinducedgrowthfactor(FIGF),isavascularendothelialgrowthfactor.Thissecretedproteinisamemberoftheplateletderivedgrowthfactor/vascularendothelialgrowthfactor(PDGF/VEGF)familyandperformsactivitiesinangiogenesis,lymphangiogenesis,andendothelialcellgrowth.HumanVEGF-Disexpressedinadultlung,heart,muscle,andsmallintestine,andismostabundantlyexpressedinfetallungsandskin.ItisstructurallyandfunctionallysimilartoVEGF-C,andissecretedasanon-covelenthomodimerinaantiparallelfashion.VEGF-Dundergoesacomplexproteolyticmaturation,generatingmultipleprocessedformswhichbindandactivateVEGFR-2andVEGFR-3receptors.LikeVEGFC,itmayparticularlybeinvoledintheformationofthevenousandlymphaticvascularsystemsduringembryogenesis,andalsointhemaintenanceofdifferentiatedlymphaticendotheliuminadults.