ReliaTech/Mouse AntiHuman TIE2FITC/101M54FITC/50 µg

Clone/ABfeature:

(#tek16)

Antibodygeneration:

ThemonoclonalantibodywasproducedwiththehelpofBALB/cmiceusingrecombinanthumansolubleextracellularTIE-2astheimmunizingantigen.MouseIgG1antibody(#tek16)fromhybridomaswaspurifiedfromcellculturesupernatantbyProteinGchromatographyandthenbiotinylatedusingastandardprotocol.TheunconjugatedantibodywilldetectnativehumanTIE-2/tekinELISAexperimentsandonthesurfaceofdifferenthumancelltypes.

Antigen:

recombinanthumansolubleextracellularTIE-3

Stability:

Storeprotectedfromlightat2-8°C.DONOTFREEZE!

Description:

Tie-1/TieandTie-2/Tekarereceptortyrosinekinaseswithuniquestructuralcharacteristicsincludingtwoimmunoglobulin-likedomainsflankingthreeepidermalgrowthfactor(EGF)-likedomains,followedbythreefibronectintypeIII-likerepeatsintheextracellularregion,andasplittyrosinekinasedomaininthecytoplasmicregion.Tie-2isinvolvedinvascularstabilizationandremodeling.Althoughlesswellunderstood,Tie-1mayalsoactasanANGreceptor,possiblyincomplexwithTie-2.HumanTie-2cDNAencodesa1124aminoacid(aa)residueprecursorproteinwithan18residueputativesignalpeptide,a727residueextracellulardomainanda354residuecytoplasmicdomain.Tie-2isareceptorfortheangiopoietin(ANG)family:ANG-1,ANG-2,andANG-3(mouse)/-4(human).Ang-2hasbeenreportedtoactasanantagonistforAng-1.MiceengineeredtooverexpressAng-2ortolackAng-1orTie-2displaysimilarangiogenesisdefects.