产品资料

StressMarq/Anti-JAK3 Antibody/SPC-1151D-HRP/100-µl

Overview:

Product Name JAK3 Antibody

Description

Rabbit Anti-Human JAK3 Polyclonal

Species Reactivity Human, Mouse

Applications WB, AM

Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.

Host Species Rabbit

Immunogen Species Human

Immunogen Synthetic peptide of human JAK3 (AA1110-1124)

Conjugates

Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature	-20ºC
Shipping Temperature	Blue Ice or 4ºC
Purification	Peptide Affinity Purified
Clonality	Polyclonal
Specificity	Detects 125.016 kDa.
Cite This Product	StressMarq Biosciences Cat# SPC-1151, RRID: AB_2711117
Certificate of Analysis	A 1:250 dilution of SPC-1151 was sufficient for detection of JAK3 in 10 µg of Jurkat cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names	EC 2.7.10.2 Antibody, JAK 3 Antibody, JAK L Antibody, JAK3 HUMAN Antibody, Janus kinase 3 (a protein tyrosine kinase, leukocyte) Antibody, Janus kinase 3 Antibody, L JAK Antibody, Leukocyte janus kinase Antibody, Protein tyrosine kinase leukocyte Antibody, Tyrosine protein kinase JAK3 Antibody
Cellular Localization	Endomembrane system, Nucleus
Accession Number	NP_000206
Gene ID	3718
Swiss Prot	P52333
Scientific Background	JAK3 is a protein-tyrosine kinase and it is involved in cytokine receptor-mediated intracellular signal transduction, including activation of an oncoprotein, PI3K. Mutations in this gene have been found in blood, mouth, and ovarian cancers.

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HRP (Horseradish peroxidase)

Properties:

Enzymatic activity is used to amplify weak signals and increase visibility of a target
Readily combines with hydrogen peroxide (H₂O₂) to form HRP-H₂O₂ complex which can oxidize various hydrogen donors
Catalyzes the conversion of:
- Chromogenic substrates (e.g. TMB, DAB, ABTS) into coloured products
- Chemiluminescent substrates (e.g. luminol and isoluminol) into light emitting products via enhanced chemiluminescence (ECL)
- Fluorogenic substrates (e.g. tyramine, homovanillic acid, and 4-hydroxyphenyl acetic acid) into fluorescent products
High turnover rate enables rapid generation of a strong signal
44 kDa glycoprotein
Extinction coefficient: 100 (403 nm)
Applications: Western blot, immunohistochemistry, and ELISA

HRP Datasheet