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StressMarq/Anti-MAPK4 Antibody (pSer186)/SPC-976D/100-µl188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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StressMarq/Anti-MAPK4 Antibody (pSer186)/SPC-976D/100-µl

Overview:

Product Name MAPK4 Antibody (pSer186)
Description

Rabbit Anti-Human MAPK4 (pSer186) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Ser186 of human MAPK4 (AA183-190)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 62.623 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-976, RRID: AB_2707967
Certificate of Analysis A 1:250 dilution of SPC-976 was sufficient for detection of MAPK4 (pSer186) in 10 µg of mouse brain lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names ERK4 Antibody, ERK3 Antibody, ERK3 related Antibody, MAPK4 Antibody, Extracellular signal regulated kinase 4 Antibody, MAP kinase 4 Antibody, MAP kinase isoform p63 Antibody, MAPK4 Antibody, Mitogen activated protein kinase 4 Antibody, MK04_HUMAN Antibody, p63MAPK Antibody, PRKM4 Antibody
Cellular Localization Cytoplasm, Nucleus
Accession Number NP_002738
Gene ID 5596
Swiss Prot P31152
Scientific Background MAPK4 is a protein-serine/threonine kinase that phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. MAPK4 may promote entry in the cell cycle.

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