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TOKU-E/Atovaquone/A099/50 mg

Atovaquoneisahydroxynaphthoquinoneantimicrobialcompoundwithantipneumocysticandanti-parasiticproperties.

    CASNumber

    95233-18-4

    MolecularFormula

    C22H19ClO3

    MolecularWeight

    366.837

    MechanismofAction

    Atovaquoneinhibitscytochromebc1oftheelectrontransportsystemleADIngtofailureofmitochondrialfunction.

    StorageConditions

    -20°C

    Spectrum

    AtovaquoneisactiveagainstPlasmodiumspp,Pneumocystiscarinii,andToxoplasmagondiiinvivoandinvitro.

Specifications:

    Form

    Powder

    Appearance

    Yellowpowder

    Source

    Synthetic

    ImpurityProfile

    RelatedSubstances(HPLC):
    RRT-0.63:Notmorethan0.5%
    RRT-0.89:Notmorethan0.3%
    RRT-1.8:Notmorethan0.5%
    RelatedCompoundA:Notmorethan1.0%
    Anyotherimpurity:Notmorethan0.2%
    Totalotherimpurities:Notmorethan1.0%
    Totalimpurities:Notmorethan1.5%

    WaterContent(KarlFisher)

    Notmorethan1.0%

    Assay

    (HPLC):97.5%-101.5%

    ResidueOnIgnition

    Notmorethan0.1%

    HeavyMetals

    Notmorethan10ppm

    ResidualSolvents

    Methanol:Notmorethan2000ppm
    Chloroform:Notmorethan60ppm
    Dichloromethane:Notmorethan600ppm
    Acetonitrile:Notmorethan410ppm

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