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Tonbo Biosciences/Recombinant Human BMP-3 (Carrier-free)/21-7172-U010 /10 µg

BoneMorphogeneticProteins(BMPs)belongtotheTGF-betasuperfamilyofproteins.BMPselicittheireffectsbysignalingthroughserine/threoninekinasereceptorsandplaykeyrolesinthedevelopmentofnearlyallorgansandtissues.BMP-3,alsoknownasosteogenin,isthemostabundantBMPinadultboneandisanapparentinhibitorofpro-osteogenicBMPs.BMP-3activatestheTGF-beta/activinpathwaywhichmayantagonizetheBMPpathway.
NameRecombinantHumanBMP-3(Carrier-free)
Cat.No.21-7172
AlternativeNamesBoneMorphogenicProtein-3,Osteogenin,BMP-3A
AminoAcidSequenceMQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR
AuthenticityVerifiedbyN-terminalandMassSpectrometryanalyses(whenapplicable).
BioactivityInhibitionofBMP-2-inducedalkalinephosphataseproductionbyATDC-5cellsismeasured.
EndotoxinLevelEndotoxinlevelis<0.1 ng/μg of protein (<1 EU/μg).
MolecularMassRecombinantHumanBMP-3is25.2kDahomodimericdisulfide-linkedproteinconsistingofaminoacids361to472oftheprecursorprotein.
ProteinContentContentVerifiedbyUVSpectroscopyand/orSDS-PAGEgel.
Purity(%)95
SourceE.coli
ReactivityHuman
ResearchAreasAngiogenesis&Cardiovascular,Differentiation,BoneandCartilage,Apoptosis,Proliferation,TGF-betaSuperfamily,StemCells
ReconstitutionSeeCertificateofAnalysis(COA)forlotspecificreconstitutioninformation.
ApplicationsBioassay
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