GoldBio/Caffeic acid phenethyl ester/5 g/C-070-5

Caffeic acid phenethyl ester (CAPE) is the active component of propolis,a honeybee hive product. Caffeic acid phenethyl ester is a specificinhibitor of the nuclear transcription factor, NF-κB. CAPE has beenshown to significantly suppress the Lipoxygenase pathway of arachidonicacid metabolism during inflammation. Caffeic acid phenethyl esterinhibits HIV-1 integrase, and also inhibits proliferation of transformedcells. It induces apoptosis in transformed fibroblasts, and interfereswith EGF signal transduction affecting both protein kinase C andOrnithine Decarboxylase activity.

Product SpecificationsCaffeic acid phenethyl esterPhenethyl 3,4-Dihydroxycinnamate; CAPEMOLECULAR BIOLOGY GRADEFormula: C₁₇H₁₆O₄MW: 284.310 g/molSlightly off-white to yellowish crystalline powderStorage/Handling: Store desiccated at -20°C. Protect from light.PubChem ID:5281787References:1. Grunberger, D. et al. Preferential cytotoxicity on tumor cells by caffeic acid pheethyl ester isolated from propo lis. Experienta 1988, 44, 230-232 2.2. Fesen, M.R., et al., In hibitors of human immunodeficiency virus integrase. Proc . Natl. Acad. Sci. USA 1993, 90, 2399-2403 3.3. SudÕina, G.F., et al., Caffeic acid phenetyl ester as a lipoxygenase inhib itor with antioxidant properties. FEBS Lett. 1993, 329, 21-24 4. 4. Fesen M.R., et al., Inhibitiion of HIV-1-integrase by flavones, caffeic acid phenethyl ester (CAPE) and rel ated compounds. Biochem. Pharmacol. 1994, 48, 595-608 5.5. Zhe ng, Z.S., et al., Caffeic acid phenetyhl ester inhibits prol iferation of human keratinocytes and interferes with the EGF regualton of ornithine decarboxylase. Oncol. Res. 1995, 7, 445-452 6. 6. Mirzoeva, O.K., and Calder, P.C., The effect of propolis and its components on eicosanoid production duri ng inflammatory response. Prostaglandins Leukot. Essent. Fatty Acides 1996, 55, 441-449 7. 7. Natarajan, K. et al., Caf feic acid phenethyl ester as a potetnt and specific inhibito r of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. USA 1996, 93, 9090 - 9095