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Adipogen/(+)-Catechin . hydrate/AG-CN2-0407-M500/500 mg

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ProductDetails
Synonyms	Cianidanol;Cyanidol;Catechol;Catechuicacid;NSC2819;(+)-3,3",4",5,7-Flavanpentol
ProductType	Chemical
Properties
Formula	C₁₅H₁₄O₆.H₂O
MW	290.3.18.0
MerckIndex	14:1902
CAS	225937-10-0or88191-48-4
Source/HostChemicals	IsolatedfromUncariarhynchophylla.
PurityChemicals	≥95%(NMR)
Appearance	Off-whitepowder.
Solubility	SolubleinDMSO,ethanolordimethylformamide.Sparinglysolubleinwater.
Identity	Determinedby¹H-NMR.
InChiKey	OFUMQWOJBVNKLR-NQQJLSKUSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
HandlingAdvice	Keepcoolanddry. Keepunderinertgas. Protectfromlight.
Use/StABIlity	Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Afterreconstitution,preparealiquotsandstoreat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Specifichistidinedecarboxylaseinhibitor[1].
Anti-inflammatory.COX-1inhibitor[2].
Antioxidantflavonoid.FreerADIcalscavenger.Inhibitslipidperoxidation[3,6,9].
Antimetastaticandanticancercompound[4,9,10,14,16,17].
Antiangiogenic[14].
Anti-osteoporotic[5].
Antibacterialandantifungal[7].
Neuroprotective[8].MonooxidaseBinhibitor[11].
Apoptosisandcellcyclearrestinducer[9,10,16,17].
JNKphosphorylationinhibitor[12].
Antispasmodic[13].
Insulin-mimetic[15].

ProductReferences

Histamineandacutehaemorrhagiclesionsinratgastricmucosa:preventionofstressulcerformationby(+)-catechin,aninhibitorofspecifichistidinedecarboxylaseinvitro:H.J.Reimann,etal.;AgentsActions7,69(1977)
Flavan-3-olsisolatedfromsomemedicinalplantsinhibitingCOX-1andCOX-2catalysedprostaglandinbiosynthesis:Y.Noreen,etal.;PlantaMed.64,520(1998)
(+)-Catechinasantioxidant:mechanismspreventinghumanplasmaoxidationandactivityinredwines:S.B.Lotito&C.G.Fraga;Biofactors10,125(1999)
Flavonoidsasanticanceragents:structure-activityrelationshipstudy:M.Lopez-Lazaro;Curr.Med.Chem.AnticancerAgents 2,691(2002)(Review)
Effectsof(+)-catechinonthefunctionofosteoblasticcells:E.M.Choi&J.K.Hwang;Biol.Pharm.Bull.26, 523(2003)
Dietarysupplementationof(+)-catechinprotectsagainstUVB-inducedskindamagebymodulatingantioxidantenzymeactivities:S.E.Jeon,etal.;Photodermatol.Photoimmunol.Photomed.19,235(2003)
Phytotoxicandantimicrobialactivitiesofcatechinderivatives:R.Veluri,etal.;J.Agric.FoodChem.52,1077(2004)
Catechinpolyphenols:neurodegenerationandneuroprotectioninneurodegenerativediseases:S.Mandel&M.B.Youdim;FreeRadic.Biol.Med.37,304(2004)(Review)
Agreenteacomponent,catechin,rapidlyinducesapoptosisofmyeloidleukemiccellsviamodulationofreactiveoxygenspeciesproductioninvitroandinhibitstumorgrowthinvivo:L.Gordon;Haematologica90,290(2005)
(+)-Catechin,aningredientofgreentea,protectsmurinemicrogliafromoxidativestress-inducedDNAdamageandcellcyclearrest:Q.Huang,etal.;J.Pharmacol.Sci.98,16(2005)
MonoamineoxidaseB(MAO-B)inhibitionbyactiveprinciplesfromUncariarhynchophylla:W.C.Hou;J.Ethnopharmacol.100,216(2005)
(+)-CatechinpreventsultravioletB-inducedhumankeratinocytedeathviainhibitionofJNKphosphorylation:W.B.Wu,etal.;LifeSci. 79,801(2006)
Antispasmodic,bronchodilatorandvasodilatoractivitiesof(+)-catechin,anaturallyoccurringflavonoid:M.N.Ghayur,etal.;Arch.Pharm.Res. 30,970(2007)
(+)-CatechininhibitstumourangiogenesisandregulatestheproductionofnitricoxideandTNF-alphainLPS-stimulatedmacrophages:C.Guruvayoorappan&G.Kuttan;InnateImmun.14,160(2008)
InsulinmimeticimpactofCatechinisolatedfromCassiafistulaontheglucoseoxidationandmolecularmechanismsofglucoseuptakeonStreptozotocin-induceddiabeticWistarrats:P.Daisy,etal.;Phytomedicine17,28(2010)
CatechinhydratesuppressesMCF-7proliferationthroughTP53/Caspase-mediatedapoptosis:A.A.Alshatwi;J.Exp.Clin.CancerRes.29,167(2010)
CatechinhydrateinhibitsproliferationandmediatesapoptosisofSiHahumancervicalcancercells:A.A.Al-Hazzani&A.A.Alshatwi;FoodChem.Toxicol.49,3281(2011)

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Adipogen/(+)-Catechin . hydrate/AG-CN2-0407-M500/500 mg