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Adipogen/Nexturastat B/AG-CR1-3902-M001/1 mg

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Product Details
Synonyms 4-((1-Butyl-3-(1H-indazol-6-yl)ureido)methyl)-N-hydroxybenzamide
Product Type Chemical
Properties
Formula C20H23N5O3
MW 381.4
CAS 1648893-33-7
Purity Chemicals ≥98% (HPLC)
Appearance Off white solid.
Solubility Soluble in DMSO, methanol or ethanol.
Identity Determined by 1H-NMR.
InChi Key SDIVUCIYBAWAQP-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50=3nM). Displays high selectivity over HDAC1 (300-fold).
  • More soluble analog of nexturastat A (Prod. No. AG-CR1-3901).
  • Suppresses cell proliferation of B16 cells (GI50=14.3µM) and human lymphoma cells HuT-78 at a slightly lower concentration than nexturastat A.
  • Shown to be effective in a mouse melanoma tumor xenograft model, increasing tumor volumes in vivo.
  • Down-regulates the production of IL-10.
  • HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Product References
  1. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation: K.V. Woan, et al.; Mol. Oncol. 9, 1447 (2015)
  2. Exploration of some new HDAC inhibitors for cancer and CNS diseases: A.P. Kozikowski; 13th Annual Discovery on Target (presentation) (2015)
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