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Adipogen/SB590885/SYN-1077-M005/5 mg

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ProductDetails
SynonymsSB-590885
ProductTypeChemical
Properties
FormulaC27H27N5O2
MW453.5
CAS405554-55-4
PurityChemicals≥95%
AppearanceSolid.
SolubilitySolubleinDMSOorethanol.
DeclarationManufacturedbySynKinase.
OtherProductDataTarget:ARaf-Raf-CRaf-BRaf|KinaseGroup:TKL|Substrate:Serine-Threonine

ClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKeyMLSAQOINCGAULQ-QFMPWRQOSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StABIlityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
SB-590885isanovel,potentandselectivesmallmoleculeinhibitorofB-Rafkinase,withaKiof0.16nM.Itshowsan11-foldgreaterselectivityforB-Rafoverc-Raf.ItwasusedtoaddressthedependenceofMAPKsignallingandtumorcellgrowthonB-Rafkinaseactivity.
ProductReferences
  1. DemonstrationofagenetictherapeuticindexfortumorsexpressingoncogenicBRAFbythekinaseinhibitorSB-590885:A.J.King,etal.;CancerRes.66,11100(2006)
  2. ThecombinationofRAF265,SB590885,ZSTK474onthyroidcancercelllinesdeeplyimpactonproliferationandMAPKandPI3K/Aktsignalingpathways:S.Barollo,etal.;Invest.NewDrugs32,626(2014)
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