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IQ Products/Fetal Cell Count™ Kit/IQP-363

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Introduction

Detectionandquantificationoffetalredbloodcells(fRBCs)inmaternalbloodsamplesisessentialforobstetricalmanagement.MeasurementoffRBCsiscriticalastheextentofFetomaternalHemorrhage(FMH),thetransplacentalpassageoffRBCsintothematernalcirculation,hasconsequencesforfurthertreatmentofmotherandchild.FrequencyandsizeofFMHisdirectlyinfluencedbycomplicationsinaBDominaltrauma,sUSPectedplacentalinjuryorafteracaesareansection.SevereFMHmayleadtointra-uterinedeath.IncaseofantigenincompatibilitybetweenmotherandchildFMHmayresultinrespiratoryproblemsoranaemia,likeHaemolyticDiseaseoftheNewborn.

AdultRBC’scontainsapopulationofHbF(F-cells),whichcanbedifferbetween0and14%.TheF-cellscangiveapositiveresultintheKleihauer-Betkeacid-elutiontestorsingleHbFflowcytometrytest.TheseF-cellsmaybetheresultofphysiologicalvariationsduringpregnancyortraitssuchasthalassemia,sicklecellanaemiaorhereditarypersistenceoffetalhaemoglobin.

Thedetection(andthusenumeration)offRBCsisusedtocalculatetheextentofFMH,eitherincaseoftraumawithsuspectedplacentalinjuryorinthesituationofaRhDincompatibilitybetweenthefetusandthemother.TheamountoffRBCsisameasureforthepreventionofhemolyticdiseaseofthenewbornusing(prophylactic)anti-Dtherapy.

PrincipleoftheFetalCellCount™Kit

TheFetalCellCount™Kitassayisaflowcytometryproduct.Theassayisbasedona patentedcombinationoftwoantibodies.OneisdirectedagainstHbFwhilethesecondisspecificforcarbonicanhydrase(CA),anenzymepresentinadultRBCsand,atverylowdetectablelevel,inlatepregnancystage.•   Resultswithin90minutes•   PreciseandaccuratedetectionoffRBCs•   IntracellulardetectionofHbFandCA•   DistinguishesbetweenfRBCsandmaternalF-cellsandRBCs,iteliminatessubjectiveinterpretationsanempiricsignalcutoffsCytogramm_FetalCellCount_Kit - IQ ProductsCytogramsillustratingtypicaldataobtainedwiththeFetalCellCountKitA1;fetalRBCs/A2;F-cells/A4;maternalRBCs.

ConclusionThedatademonstratetheusefulnessofCAasaredbloodcellMarker.Itallows,incombinationwithHbF,anaccuratediscriminationbetweenthedifferentRBCpopulationsinmaternalblood.Withouttheuseofthissecondmarker,discriminationbetweenthefetalRBCsandthevariableconcentrationsofHbFcontainingmaternalF-cellsbecomeslessprecise.

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