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Sciencell/Recombinant Human Fibroblast Growth Factor-19/104-19/1 Ea

Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
Fibroblastgrowthfactor19(FGF-19)belongstothelargeFGFfamilywhichhasatleast23members.However,FGF-19,alongwithFGF-21andFGF-23,belongstoasubfamilyofatypicalFGFswhereitlacksaconventionalheparin-bindingmotif.Therefore,itssignaltransductionismediatedbythecofactor?KlothowheninteractingwithFGFRs1c,2cand3c.Interestingly,FGF-19caninteractdirectlywithFGFR4inabsenceof?Klotho.FGF-19regulatesmetabolicprocessesincludingbileacid,lipidandglucosehomeostasis,aswellashepatocyteproliferation.AdmiNISTrationofrecombinantFGF-19tomicedecreasedcholesterol7-alpha-hydroxylase(CYP7A1)expression,theratelimitingstepinbileacidbiosynthesispathwayintheliver.

Specifications:

CatalogNo.104-19
CountryofManufactureUnitedStates
ProductCoderhFGF-19
Size/Quantity5μg
ProductUseThisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
StorageStoreat-20°Cafterreceiving.UponReconstitution,storeat2-8°Cforuptooneweek.FormaximalstABIlity,aliquotandstoreat-20°C.Avoidrepeatedfreeze/thawcycles.
ShippingInfoDryice
SynonymsFGF19
AASequenceMRPLAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEPEDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK
SourceEscherichiacoli
MolecularWeightApproximately21.8kDa,asinglenon-glycosylatedpolypeptidechaincontaining195aminoacids.
Purity>95%bySDS-PAGEandHPLCanalyses.
BIOLOGicalActivityFullybiologicallyactive.TheED50is100-150ng/ml,asdeterminedbyproliferationofBALB/c3T3cells.
PhysicalAppearanceWhitelyophilizedpowder.
FormulationLyophilizedfroma0.2μmfilteredconcentratedsolutioninPBS,pH7.4.
Endotoxin
ReconstitutionReconstituteinsteriledistilledwatercontaining0.1%BSAtoaconcentrationof0.1-1.0mg/mL.
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