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eEnzyme/Beta-2 Adrenergic Receptor (ADRB2) ACTOneTM Stable Cell/CL-01-ADRB2

CL-01-ADRB2

Name

Beta-2 Adrenergic Receptor (ADRB2) ACTOneTM Stable Cell Line

Description

This cell line is a HEK-293-CNG cell line that expresses a recombinant human ADRB1. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.

Application

cAMP dependent human ADRB2 cell-based assay;

Cell-based high-throughput screening of human ADRB2 agonists/antagonists.

Size

1x 106 cells

Detection

FlexStation or microplate reader

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