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LKT/SOTALOL HYDROCHLORIDE/S5976/25 mg

ProductIDS5976
CasNo.959-24-0
Purity≥98%
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

Sotalolisanon-selectiveinhibitorofβ-adrenergicreceptorsthatalsoinhibitsNa+andK+channels.SotalolactsasaclassIIIanti-arrhythmicdrugthatalsoexhibitsanti-fibrillatoryactivity.Sotalolisusedclinicallytotreatventricularfibrillationandventriculartachycardia.Invitroandinvivo,sotalolprolongsactionpotentialduration,QTandPRintervals,andincreasestheeffectiverefractoryperiod.

ProductInfo

CasNo.

959-24-0

Purity

≥98%

Formula

C12H20N2O3S•HCl

FormulaWt.

308.82

IUPACName

N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride

MeltingPoint

206.5-207°C

Appearance

Whitetooffwhitepowder

ShippingandStorage

StoreTemp

Ambient

ShipTemp

Ambient

Downloads

MSDS

S5976MSDSPDF

InfoSheet

S5976InfoSheetPDF

References

BurashnikovA,PourrierM,GibsonJK,etal.Rate-dependenteffectsofvernakalantintheisolatednon-remodeledcanineleftatriaareprimarilyduetoblockofthesodiumchannel:comparisonwithranolazineanddl-sotalol.CircArrhythmElectrophysiol.2012Apr;5(2):400-8.PMID:22322366.

ShahSA,KlugerJ,WhiteCM.MonotherapyversuscombinationtherapywithclassIIIantiarrhythmicagentstoattenuatetransmuraldispersionofrepolarization:apotentialriskfactorfortorsadedepointes.Pharmacotherapy.2007Sep;27(9):1297-305.PMID:17723083.

SinghBN,SinghSN,RedaDJ,etal.Amiodaroneversussotalolforatrialfibrillation.NEnglJMed.2005May5;352(18):1861-72.PMID:15872201.

BorianiG,LubinskiA,CapucciA,etal.Amulticentre,double-blindrandomizedcrossovercomparativestudyontheefficacyandsafetyofdofetilidevssotalolinpatientswithinducIBLesustainedventriculartachycardiaandischaemicheartdisease.EurHeartJ.2001Dec;22(23):2180-91.PMID:11913480.

TouboulP,AtallahG,KirkorianG,etal.Clinicalelectrophysiologyofintravenoussotalol,abeta-blockingdrugwithclassIIIantiarrhythmicproperties.AmHeartJ.1984May;107(5Pt1):888-95.PMID:6720518.

GiudicelliJF,LhosteF,BoissierJR.Beta-adrenergicblockadeandatrio--ventricularconductionimpairment.EurJPharmacol.1975Apr;31(2):216-25.PMID:238853.

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