GSK-429286A is an inhibitor of ROCK1/2 that also exhibits some inhibition of RSK and p70S6K. GSK-429286A displays antihypertensive activity, decreasing mean arterial pressure in spontaneously hypertensive rats.
| Cas No. | 864082-47-3 |
|---|---|
| Purity | ≥98% |
| Formula | C21H16F4N4O2 |
| Formula Wt. | 432.37 |
| IUPAC Name | N-(6-fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide |
| Synonym | GSK429286A |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | G7443 Info Sheet PDF |
|---|
Nichols RJ, Dzamko N, Hutti JE, et al. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424(1):47-60. PMID: 19740074.
Goodman KB, Cui H, Dowdell SE, et al. Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50(1):6-9. PMID: 17201405.
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