Polyclonal antibody (host rabbit). IgG fraction purified by immobilized Protein A.
Gene ID: 18791Swiss-Prot/UniProt ID: P11214
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| Purity | IgG fraction |
|---|---|
| Source | Rabbit serum |
| Molecular Weight | 160,000 |
| Target Molecular Weight | 70,000 |
| Extinction Coefficient | 1.36 |
| Antigen | Recombinant full length wild-type mouse protein (Glycosylated). |
| Epitope | Recognises Tissue Plasminogen Activator (tPA) |
| Cross Reactivity | Ms, Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Species | Mouse |
| Storage | -70 C |
| Shipping Conditions | Dry ice |
| Expiration | 5 years from delivery |
| Form | Frozen liquid |
| Buffer | 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 |
| Sample Size | 1.0 mg |
| Sample Concentration | 10.0 mg/ml |
| Sample Volume | 0.1 ml |
| Applications | ELISA, Immunohistochemistry (frozen sections), Immunoprecipitation, Western Blot |
| Gene Name | PLAT |
| Gene ID | 18791 |
| UniProt ID | P11214 |
1. Zaitsev S, Danielyan K, Murciano JC et-al. Human complement receptor type 1-directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis. Blood. 2006;108 (6): 1895-902. doi:10.1182/blood-2005-11-012336 – Free text at pubmed – Pubmed citation
2. Adhami F, Yu D, Yin W et-al. Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. Am. J. Pathol. 2008;172 (6): 1704-16. doi:10.2353/ajpath.2008.070979 – Free text at pubmed – Pubmed citation
3. Sundaram JR, Chan ES, Poore CP et-al. Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration. J. Neurosci. 2012;32 (3): 1020-34. doi:10.1523/JNEUROSCI.5177-11.2012 – Pubmed citation
4. Bi oh S, Suh N, Kim I, Lee JY. Impacts of aging and amyloid-β deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimer’s disease. Brain Res. 2015;1597:159-67. – link to article
5. Cooper JM, Rastogi A, Krizo JA, Mintz EM, Prosser RA. Urokinase-type plasminogen activator modulates mammalian circadian clock phase regulation in tissue-type plasminogen activator knockout mice. Eur J Neurosci. 2016; Link to article
6. Rzeczycki, P. The Role of Macrophages in the Sequestration of Drug and Formation of Insoluble Drug Aggregates. Link to article
7. Singh S, Houng A, Reed GL. Releasing the Brakes on the Fibrinolytic System in Pulmonary Emboli: Unique Effects of Plasminogen Activation and α2-Antiplasmin Inactivation. Circulation. 2017;135(11):1011-1020. Link to article
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