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| SPECIES: | Human |
|---|---|
| SOURCE SPECIES: | HEK293 cells |
| SEQUENCE: | Met 1 - Ala 54 |
| FUSION TAG: | Fc Tag |
| TESTED APPLICATIONS: | ELISA, WB |
| APPLICATIONS: | This recombinant protein can be used for E, WB. For research use only. |
| BIOLOGICAL ACTIVITY: | Measured by its binding ability in a functional ELISA. Immobilized Human BAFF, Fc Tag at 10 ug/mL (100 uL/well) can bind FITC-Labeled Human BCMA, Fc Tag with a linear range of 0.15-0.625 ug/mL (QC tested). |
| PURITY: | >92% as determined by SDS-PAGE. Endotoxin level is less than 1.0 EU per ug by the LAL method. |
|---|---|
| PREDICTED MOLECULAR WEIGHT: | 32 kDa |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | PBS, pH7.4 |
| STORAGE CONDITIONS: | Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles. Avoid exposure to light. |
| ALTERNATE NAMES: | TNFRSF17,CD269,BCM,BCMA |
|---|---|
| ACCESSION NO.: | Q02223 |
| Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK. |
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