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Abcam/Thapsigargin, Ca2+-ATPase inhibitor (ab120286)/1/ab120286

Overview

  • Product name

    Thapsigargin, Ca2+-ATPase inhibitor

  • Description

    Ca2+-ATPase inhibitor

  • Biological description

    A potent, cell-permeable Ca2+-ATPase inhibitor. Releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM). Both tumorogenic and apoptotic actions reported.

  • Purity

    >98%

  • CAS Number

    67526-95-8

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate

  • Molecular weight

    650.76

  • Molecular formula

    C34H50O12

  • PubChem identifier

    446378

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC=C(C)C(=O)O[C@@H]3[C@@H](OC(=O)CCCCCCC)[C@H]1C([C@@H]2OC(=O)[C@](O)(C)[C@@]2(O)[C@H](C[C@]1(C)OC(C)=O)OC(=O)CCC)=C3C

  • Source

    Thapsia garganica

  • Research areas

    • Tags & Cell Markers
    • Subcellular Markers
    • Organelles
    • ER
    • Signal Transduction
    • Signaling Pathway
    • Calcium Signaling
    • Calcium Channels
    • Signal Transduction
    • Metabolism
    • Plasma Membrane
    • ATPases
    • Neuroscience
    • Neurotransmitter
    • Transporters
    • Other Transporters
    • Cardiovascular
    • Atherosclerosis
    • Hypertension
    • Sodium/ion transport
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Enzymes
    • ATPase & GTPase
    • Inhibitors
    • Biochemicals
    • Pharmacology
    • Signaling
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Transporters
    • Ion pumps / transporter
    • Ca2+-ATPase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Heart disease
    • Calcium
    • Metabolism
    • Types of disease
    • Heart disease
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Alzheimer"s Disease
    • Signaling
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Diabetes
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Heart disease
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Hypertension
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Obesity
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Stroke
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Ca2+ signaling
    • Ca2+-ATPase
    • Biochemicals
    • Research Area
    • Cancer
    • Ca2+ signaling
    • Ca2+-ATPase
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