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Human MHC Class II (HLA-DP, DQ & DR) molecules are expressed on dendritic cells, monocytes, macrophages, and myeloid beta cells. MHC Class II molecules are heterodimers of polymorphic transmembrane a and b chains and generally bind exogenously derived peptides of about 10-17 amino acids. MHC Class II molecules interact with the T cell receptor on CD4+ T cells.
Isotype: Murine IgG1
Immunogen: Purified (With Antibiotics) class II from JY cell line
Specificity: Antibody TDR31.1 recognizes a monomorphic class II beta chain epitope (1), and has been termed a “pan HLA II beta mAb” (8) since it cross reacts with other HLA haplotypes (7).
References:
1. T.A. deKrester, et al, (1982) Eur J Immunol 12: 214-221.
2. R. Busch & J.B. Rothbard, (1990) J Immunol Methods 134: 1-22.
3. K.W. Wacherpfennig & J.L. Strominger, (1995) J Exp Med 181: 1597-1601.
4. Whitwell H L, A Ahmed, et al. (1984) Br J Cancer 49: 161-172.
5. Keller C W, J D Lunemann, et al. (2010) J Biol Chem 286(5): 3970-3980.
6. Yang J, T Mohanakumar, et al. (2004) Human Immunol 65: 692-699.
7. D M Altmann, Trowsdale J, et al. (1990) Immunogenetics 32(1): 51-55. PMID: 1695613
8. Miyadera H, K Tokunaga, et al. (2015) J Clin Invest 125(1): 275-91. PMID 25485681
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