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DatasheetMSDS| CAS No | 225937-10-0, 88191-48-4 |
| MW | 290.3 . 18.0 |
| Article No | AG-CN2-0407-G001 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | (+)-Catechin . hydrate |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Specific histidine decarboxylase inhibitor. Anti-inflammatory. COX-1 inhibitor. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation. Antimetastatic and anticancer compound. Antiangiogenic. Anti-osteoporotic. Antibacterial and antifungal. Neuroprotective. Mono oxidase B inhibitor. Apoptosis and cell cycle arrest inducer. JNK phosphorylation inhibitor. Antispasmodic. Insulin-mimetic. |
| Molecular Formula | C15H14O6 . H2O |
| Alias Names | Cianidanol; Cyanidol; Catechol; Catechuic acid; NSC 2819; (+)-3,3",4",5,7-Flavanpentol |
| Product Type | Chemicals & Biochemicals |
| Purity | >95% (NMR) |
| References | Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro: H.J. Reimann, et al.; Agents Actions 7, 69 (1977) | Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis: Y. Noreen, et al.; Planta Med. 64, 520 (1998) | (+)-Catechin as antioxidant: mechanisms preventing human plasma oxidation and activity in red wines: S.B. Lotito & C.G. Fraga; Biofactors 10, 125 (1999) | Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002) (Review) | Effects of (+)-catechin on the function of osteoblastic cells: E.M. Choi & J.K. Hwang; Biol. Pharm. Bull. 26, 523 (2003) | Dietary supplementation of (+)-catechin protects against UVB-induced skin damage by modulating antioxidant enzyme activities: S.E. Jeon, et al.; Photodermatol. Photoimmunol. Photomed. 19, 235 (2003) | Phytotoxic and antimicrobial activities of catechin derivatives: R. Veluri, et al.; J. Agric. Food Chem. 52, 1077 (2004) | Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases: S. Mandel & M.B. Youdim; Free Radic. Biol. Med. 37, 304 (2004) (Review) | A green tea component, catechin, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo: L. Gordon; Haematologica 90, 290 (2005) | (+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest: Q. Huang, et al.; J. Pharmacol. Sci. 98, 16 (2005) | Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla: W.C. Hou; J. Ethnopharmacol. 100, 216 (2005) | (+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) | Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) | (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages: C. Guruvayoorappan & G. Kuttan; Innate Immun. 14, 160 (2008) | Insulin mimetic impact of Catechin isolated from Cassia fistula on the glucose oxidation and molecular mechanisms of glucose uptake on Streptozotocin-induced diabetic Wistar rats: P. Daisy, et al.; Phytomedicine 17, 28 (2010) | Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis: A.A. Alshatwi; J. Exp. Clin. Cancer Res. 29, 167 (2010) | Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells: A.A. Al-Hazzani & A.A. Alshatwi; Food Chem. Toxicol. 49, 3281 (2011) |
| Research Area | Metabolism |
| Shipping Information | RT |
| Size | 1 g |
| Solubility | Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water. |
| Source / Host | plant |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C. |
| Storage | 4°C |
| Technical Specifications | Chemical. CAS: 225937-10-0 or 88191-48-4. Formula: C15H14O6 . H2O. MW: 290.3 . 18.0. Isolated from Uncaria rhynchophylla. Specific histidine decarboxylase inhibitor. Anti-inflammatory. COX-1 inhibitor. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation. Antimetastatic and anticancer compound. Antiangiogenic. Anti-osteoporotic. Antibacterial and antifungal. Neuroprotective. Mono oxidase B inhibitor. Apoptosis and cell cycle arrest inducer. JNK phosphorylation inhibitor. Antispasmodic. Insulin-mimetic. |
| Product Page Updated | 2020-07-01T08:42:19.743Z |
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