产品资料

Osenses/Rabbit antibody to COX2/100 µl/OSC00198W

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSC00198W

$240USD Buy Now

ID Tag

Rb1202-051209-WS

Immunogen

A synthetic peptide to n-terminal region of human COX2 (Cytochrome c oxidase subunit 2) conjugated to an immunogenic carrier protein was used as the antigen.

Accession

COX2_HUMAN

Also known

Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II, COXII, COII

Target

FUNCTION: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Anderson S, et al. Nature 290:457-465(1981)2. Moilanen J.S, et al. Mol. Biol. Evol. 20:2132-2142(2003)3. Ingman M, et al. Nature 408:708-713(2000)

Limitation

For research use only

Code

OSC00198W

$240USD Buy Now

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for COXII.

Spcs X-react.

Human. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSC00198W

$240USD Buy Now

PDF Data Sheet

- Click to download the Data Sheet

MSDS

Click to download the data sheet - Click to download the Material Safety Data Sheet

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Osenses/Rabbit antibody to COX2/100 µl/OSC00198W