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Discovery Antibodies/Anti-2SC antibody/50ug/crb2005017e

Catalogue numbercrb2005017AntibodyAnti-2SC antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200002eAliases S-(2-succinyl)-cysteineHost Species Anti-RabbitAntibody TypePolyclonalConcentration0.4mg/ml Glycine eluate (Rb 6773)ValidationWB (1:200), ELISA (I:1000), IHC (1:2000)Target2SCDisease AreaCancer Biology, Diabetes, Obesity, Renal cancerSpecificitySuccinated cysteine residuesPost-translational ModificationSuccinationStorage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.Citations

Burgener et al.(2019). SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.Nat Immunol. 20(10):1311-1321.PMID: 31527833

References

Alderson, N., Wang, Y., Blatnik, M., Frizzell, N., Walla, M., Lyons, T., Alt, N., Carson, J., Nagai, R., Thorpe, S. and Baynes, J. (2006). S-(2-Succinyl)cysteine: A novel chemical modification of tissue proteins by a Krebs cycle intermediate. Arch Biochem Biophys, 450(1), 1-8. PMID: 16624247

Nagai, R., Brock, J., Blatnik, M., Baatz, J., Bethard, J., Walla, M., Thorpe, S., Baynes, J. and Frizzell, N. (2007). Succination of Protein Thiols during Adipocyte Maturation: a biomarker of mitochondrial stress. J Biol Chem, 282(47), 34219-34228. PMID: 17726021

Merkley, E., Metz, T., Smith, R., Baynes, J. and Frizzell, N. (2013). The succinated proteome. Mass Spectrom Rev, 33(2), 98-109. PMID: 24115015

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