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Discovery Antibodies/(±)-Bay K8644/50 mg/B-350-50 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Discovery Antibodies/(±)-Bay K8644/50 mg/B-350-50 mg

Cat#:B-350
  • LyophilizedPowder
  • BioassayTested
    • SourceSynthetic
    MW:356.3
    Purity:>99%(HPLC)
    Effectiveconcentration1-5μM.
      • (±)-Bay K8644
    Chemicalname1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylicacid,methylester.
    MolecularformulaC16H15F3N2O4.
    CASNo.:71145-03-4,93468-89-4.
    Activity(±)-BayK8644isadihydropyridinethatactsasanL-type,voltage-gatedCa2+ channelagoNIST.The(-)-enantiomerhasstrongCa2+ channelagonistproperties,whereasthe(+)-enantiomerhasweakCa2+ channelantagonistactivity.ThenetactivityoftheracemicmixisL-typechannelopening.Inthepresenceofthisagonist,channelstendtoopenforlongerperiodscausingalargeincreaseinthechannelmicroscopicresponse1-4.(±)-BayK8644isalsoaninhibitor(byincreasingtheinactivation)ofa Shaker KV channel5.
      • Hess,P. etal. (1984) Nature 311, 538.
      • Nowycky,M.C. etal. (1985) Proc.Natl.Acad.Sci.U.S.A. 82, 2178.
      • Bechem,M.andHoffmann,H. (1993) PflugersArch. 424, 343.
      • Triggle,D.J.andRampe,D. (1989) TrendsPharmacol.Sci. 10, 507.
      • Avdonin,V. etal. (1997) J.Gen.Physiol. 109, 169.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    SolubilityEthanol,methanolorDMSO.Centrifugeallproductpreparationsbeforeuse(10000xg5min).
    StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.
      • (±)-Bay K8644
        AlomoneLabs(±)-BayK8644increasesL-typeCa2+ currentsexpressedin Xenopus oocytes.
        Left:I-Vrelationbefore(squares)andduring(circles)bathperfusionof5μM (±)-BayK8644 (#B-350).Right:Anexampleofcurrentresponseto200msdepolarizationto+20mV(fromholdingpotentialof-100mV)before(black)andduring(pink)perfusionof(±)-BayK8644.
        (±)-Bay K8644
        AlomoneLabs(±)-BayK8644modulatesthephosphorylationofERK1/2MAPKinJurkatTcells.
        CellswerepreincubatedwithorwithoutEGTAorNifedipinefor20minthenstimulatedwith (±)-BayK8644 (#B-350)orwith Ionomycin for10min.Thecellproteinswereblottedandprobedwithanti-phosphoERK1/2(upperpanel)orwithanti-ERK1/2(lowerpanel).
    References-Scientificbackground
    • 1.Hess,P. etal. (1984) Nature 311, 538.
    • 2.Nowycky,M.C. etal. (1985) Proc.Natl.Acad.Sci. U.S.A. 82, 2178.
    • 3.Bechem,M.andHoffmann,H. (1993) PflugersArch. 424, 343.

      • (±)-BayK8644isanopenerofallL-typechannels(CaV1family).Inthepresenceofthisagonist,channelstendtoopenforlongerperiodscausingalargeincreaseinthechannelmacroscopicresponse.

        Thenetactivityoftheracemicmixisthatofthe(-)-enantiomeragonisticactivity.

        (±)-BayK8644isawidelyusedL-typeCa2+channelactivatorinvariousneuronal,muscle,endocrine,thyroidandothercelltypes.1-3

    TargetL-typeCa2+ channels
    LyophilizedPowder
    receivea5mgfreetrialsample!
    Lastupdate:24/09/2019

    (±)-BayK8644(#B-350)isahighlypure,synthetic,andbiologicallyactivecompound.

    Forresearchpurposesonly,notforhumanuse
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